HIPERVITAMINOSIS D PDF

Confusion, apathy, recurrent vomiting, abdominal pain, polyuria, polydipsia, and dehydration are the most often noted clinical symptoms of vitamin D toxicity VDT; also called vitamin D intoxication or hypervitaminosis D. VDT and its clinical manifestation, severe hypercalcemia, are related to excessive long-term intake of vitamin D, malfunctions of the vitamin D metabolic pathway, or the existence of coincident disease that produces the active vitamin D metabolite locally. Although VDT is rare, the health effects can be serious if it is not promptly identified. Many forms of exogenous iatrogenic and endogenous VDT exist.

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Hypervitaminosis D is a rare but potentially serious condition. It occurs when you take in too much vitamin D.

Too much vitamin D can cause abnormally high levels of calcium in the blood. This can affect bones, tissues, and other organs. It can lead to high blood pressure , bone loss, and kidney damage if not treated. However, there have been cases reported due to tanning bed use. And there has been an increase in overall hypervitaminosis D cases in the past few years.

It is usually due to taking more than the recommended daily value of vitamin D. If you take a multivitamin, look at the amount of vitamin D in it. Some prescription medications used to treat high blood pressure thiazide diuretics and heart diseases digoxin can cause an increase in vitamin D in the blood. Estrogen therapy, taking antacids for a long time, and isoniazide, an antituberculosis medication, can also cause elevated levels of vitamin D.

The Mayo Clinic states that the recommended dietary allowance of vitamin D for most adults is international units a day IU. Doctors may prescribe higher doses to treat medical conditions such as vitamin D deficiency, diabetes , and cardiovascular disease, for a short period of time.

Daily use of high-dose vitamin D supplements for several months is toxic. You are more likely to develop hypervitaminosis D if you take vitamin D supplements and have other existing health problems, such as:. Excessive amounts of vitamin D in the body can cause calcium levels in the blood to rise. This can lead to a condition called hypercalcemia too much calcium in your blood.

Symptoms include:. Your doctor may also perform a physical exam and ask questions about your symptoms. If your doctor suspects that you may have hypervitaminosis D, they may order tests, including:. Your doctor will likely advise you to stop taking vitamin D supplements immediately.

They may also recommend that you reduce the amount of calcium in your diet temporarily. In some cases, corticosteroids or bisphosphonates may suppress the release of calcium from your bones. Discontinuing or lowering your intake of high-dose vitamin D supplements can prevent hypervitaminosis D. The tolerable upper limit, or the maximum daily intake of vitamin D that is unlikely to result in any health risks, has been set at 4, IUs per day.

Adverse effects have been seen in those taking less than 10, IUs per day over an extended period of time. Your doctor may also recommend that you lower the amount of calcium in your diet. Careful monitoring is necessary until your vitamin D levels are back to normal. You can also find foods fortified with vitamin D, including milk, orange juice, and yogurt. Moderate exposure to sunlight is another source of natural vitamin D.

Fifteen minutes or less with your extremities exposed in direct sunlight, before putting on sunscreen, is a great way to improve your vitamin D level naturally.

A review of existing research indicates that vitamin D supplements could help to ease symptoms of irritable bowel syndrome, such as abdominal pain.

Vitamin D has been found to protect the heart against heart failure following a heart attack. Now, a new study describes how this might work. Analysis of data from a large trial found calcium with and without vitamin D raised risk of colorectal polyps 6—10 years after starting on the…. Researchers have discovered that people with CVD who had vitamin D levels within the normal range were less likely to die from the disease.

Using nanosensors, scientists identified the molecular mechanisms through which vitamin D-3 restores the function of cardiovascular endothelial cells…. What's to know about hypervitaminosis D?

Medically reviewed by Debra Rose Wilson, Ph. Share on Pinterest. Share on Pinterest Some types of mushrooms contain vitamin D. Best available evidence supports physical distancing and wearing face masks. Related Coverage. Could vitamin D supplements treat IBS? How vitamin D protects against heart failure Vitamin D has been found to protect the heart against heart failure following a heart attack.

Calcium and vitamin D supplements may raise risk of polyps Analysis of data from a large trial found calcium with and without vitamin D raised risk of colorectal polyps 6—10 years after starting on the… READ MORE. Could vitamin D lower cardiovascular death risk? Vitamin D-3 could 'reverse' damage to heart Using nanosensors, scientists identified the molecular mechanisms through which vitamin D-3 restores the function of cardiovascular endothelial cells… READ MORE.

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Hypervitaminosis D

Hypervitaminosis D is a rare but potentially serious condition. It occurs when you take in too much vitamin D. Too much vitamin D can cause abnormally high levels of calcium in the blood. This can affect bones, tissues, and other organs. It can lead to high blood pressure , bone loss, and kidney damage if not treated. However, there have been cases reported due to tanning bed use.

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What's to know about hypervitaminosis D?

Hypervitaminosis D also known as vitamin D toxicity VDT is very rare, and is usually secondary to exogenous administration of megadoses of vitamin D over long periods. Clinically it manifests as the clinical sequelae of chronic hypercalcemia. Incidence is unknown, however recent interesting work suggests it is much rarer than historically used to be thought 2. Symptoms and signs of hypervitaminosis D tend to be related to the hypercalcemia and overt presentations are rare:. Markedly elevated serum levels of hydroxyvitamin D 25 OH D are key to the pathogenesis of vitamin D toxicity. Historically it was thought that as hydroxyvitamin D rose, the hypercalcemia manifested itself in step, however recent work suggests that in most people normocalcaemia persists, even in the face of a severely elevated serum 25 OH D 2.

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Vitamin D Toxicity–A Clinical Perspective

Hypervitaminosis D is a state of vitamin D toxicity. An excess of vitamin D causes abnormally high blood concentrations of calcium , which can cause overcalcification of the bones , soft tissues , heart and kidneys. In addition, hypertension can result. Hypervitaminosis D symptoms appear several months after excessive doses of vitamin D are administered. In almost every case, a low-calcium diet combined with corticosteroid drugs will allow for a full recovery within a month. It is possible that some of the symptoms of vitamin D toxicity are actually due to vitamin K depletion.

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