Citazioni per anno. Citazioni duplicate. I seguenti articoli sono uniti in Scholar. Le loro citazioni combinate sono conteggiate solo per il primo articolo. Citazioni unite.
|Published (Last):||15 October 2012|
|PDF File Size:||7.11 Mb|
|ePub File Size:||10.38 Mb|
|Price:||Free* [*Free Regsitration Required]|
Systems used to automatically annotate proteins with high accuracy:. Select item s and click on "Add to basket" to create your own collection here entries max.
Sampietro M. Mild to moderate iron overload is common in PCT, as iron is one of the factors which trigger the clinical manifestations of the disease through the inactivation of URO-D.
A role for genetic hemochromatosis in the development of iron overload in sporadic PCT has been hypothesized in the past. The aim of this work was to investigate whether mutations of HFE, which is a candidate gene for hemochromatosis, play the role of genetic susceptibility factors for PCT in Italian patients, who have a high prevalence of acquired triggering factors, such as hepatitis C virus HCV chronic infection and alcohol.
A second mutation of HFE, His63Asp, however, had a significantly increased frequency as it was present in half of the patients.
Surprisingly, the presence of the His63Asp mutation was not related to the iron status of patients, suggesting that a subtle abnormality of iron metabolism induced by this mutation could escape detection by the standard parameters of iron status.
In PCT patients with liver disease, the presence of the mutation could contribute to the inactivation of URO-D, either directly or through a synergistic action with other factors that cause liver damage.
You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser. Basket 0. Your basket is currently empty. Do not show this banner again.
Iron in Nonhemochromatotic Liver Disorders
Fulminant Hepatitis After 10 Days of Acetaminophen Treatment at Recommended Dosage in an Infant
Piperno, M. Sampietro, A. Pietrangelo, C. Arosio, L. Lupica, G.