DEDIFFERENTIATION TRANSDIFFERENTIATION AND REPROGRAMMING THREE ROUTES TO REGENERATION PDF

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A Nature Research Journal. The ultimate goal of regenerative medicine is to replace lost or damaged cells.

This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. During dedifferentiation, a terminally differentiated cell reverts back to a less-differentiated stage from within its own lineage, which allows it to proliferate. Many regenerative processes have been associated with dedifferentiation. Transdifferentiation sees cells regress to a point when they can switch lineages or can also occur directly between two different cell types.

Reprogramming aims to induce differentiated cells into reverting to pluripotency. From here, they can differentiate into almost any cell type. During dedifferentiation and transdifferentiation, well-defined intermediate cell types have been identified. The process of reprogramming seems to be largely stochastic.

Dedifferentiation and transdifferentiation can be successfully achieved in vivo , and reprogramming facilitates genetic manipulation such as correcting disease-inducing mutations. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state reprogramming but can also induce the cell to proliferate dedifferentiation or even switch to another cell type transdifferentiation.

Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine. Brockes, J. Plasticity and reprogramming of differentiated cells in amphibian regeneration. Nature Rev. Cell Biol. Wolff, G. Entwicklungsphysiologische Studien. Die Regeneration der. Wilhelm Roux' Arch. Google Scholar. Reprogramming and differentiation in mammals: motifs and mechanisms.

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Cardiac myocyte cell cycle control in development, disease, and regeneration. Advances in understanding tissue regenerative capacity and mechanisms in animals. Burkhart, D. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Cancer 8 , — Tanaka, E. Newt myotubes reenter the cell cycle by phosphorylation of the retinoblastoma protein.

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Development , — Harvey, K. The Salvador—Warts—Hippo pathway — an emerging tumour-suppressor network. Cancer 7 , — Nicolay, B. Combined inactivation of pRB and Hippo pathways induces dedifferentiation in the Drosophila retina.

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Dedifferentiation, Transdifferentiation and Reprogramming: Three Routes to Regeneration

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Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration.

The ultimate goal of regenerative medicine is to replace lost or damaged cells. This can potentially be accomplished using the processes of dedifferentiation, transdifferentiation or reprogramming. Recent advances have shown that the addition of a group of genes can not only restore pluripotency in a fully differentiated cell state reprogramming but can also induce the cell to proliferate dedifferentiation or even switch to another cell type transdifferentiation. Current research aims to understand how these processes work and to eventually harness them for use in regenerative medicine. This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

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Dedifferentiation, transdifferentiation and reprogramming: three routes to regeneration

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